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Multiomics analyses of Jining Grey goat and Boer goat reveal genomic regions associated with fatty acid and amino acid metabolism and muscle development |
Zhaohua Liu1,2 
, Xiuwen Tan1,2
, Qing Jin1
, Wangtao Zhan3
, Gang Liu3
, Xukui Cui1,2
, Jianying Wang1,2
, Xianfeng Meng1,2
, Rongsheng Zhu1,2
, Ke Wang1,2,*
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1Institute of Animal Science and Veterinary Medicine, Shandong Key Lab of Animal Disease Control and Breeding, Shandong Academy of Agricultural Sciences, Jinan 250100, China
2Key Laboratory of Livestock and Poultry Multi-omics of MARA, Jinan 250100, China
3Shandong Animal Husbandry General Station, Jinan 250100, China |
Correspondence:
Ke Wang, Tel: +86-0531-66655083, Fax: +86-0531-66655083, Email: sduwangke@163.com
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Received: 23 August 2023 • Revised: 30 September 2023 • Accepted: 31 October 2023 |
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| Abstract |
Objective
Jining Grey goat is a local Chinese goat breed that is well known for its high fertility and excellent meat quality but shows low meat production performance. Numerous studies have focused on revealing the genetic mechanism of its high fertility, but its highlighting meat quality and muscle growth mechanism still need to be studied.
Methods
In this research, an integrative analysis of the genomics and transcriptomics of Jining Grey goats compared with Boer goats was performed to identify candidate genes and pathways related to the mechanisms of meat quality and muscle development.
Results
Our results overlap among five genes (ABHD2, FN1, PGM2L1, PRKAG3, RAVER2) and detected a set of candidate genes associated with fatty acid metabolism (PRKAG3, HADHB, FASN, ACADM), amino acid metabolism (KMT2C, PLOD3, NSD2, SETDB1, STT3B, MAN1A2, BCKDHB, NAT8L, P4HA3) and muscle development (MSTN, PPARGC1A, ANKRD2). Several pathways have also been detected, such as the FoxO signaling pathway and Apelin signaling pathway that play roles in lipid metabolism, lysine degradation, N-glycan biosynthesis, valine, leucine and isoleucine degradation that involving with amino acid metabolism.
Conclusion
The comparative genomic and transcriptomic analysis of Jining Grey goat and Boer goat revealed the mechanisms underlying the meat quality and meat productive performance of goats. These results provide valuable information for future breeding of goats. |
| Keywords:
Goat; Meat Quality; Muscle Development; RNA-seq; Selective Signature |
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