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Anim Biosci > Accepted Articles
https://doi.org/10.5713/ab.21.0374    [Accepted] Published online January 4, 2022.
Effects of yeast hydrolysate supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers
Ting Wang1  , Kang Cheng1  , QiMing Li1  , Tian Wang1,* 
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China
Correspondence:  Tian Wang, Tel: +86-25-8439-6483, Fax: +86-25-8439-5314, Email: tianwangnjau@163.com
Received: 19 August 2021   • Revised: 6 October 2021   • Accepted: 16 November 2021
This study was conducted to evaluate the effects of dietary yeast hydrolysate (YH) supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers.
A total of 320 one day old male broilers were randomly allocated into four groups with eight replicates of ten broilers each. The broilers were supplemented with a basal diet (the control group) or basal diets adding 50, 100, 150 mg/kg YH, respectively. This trial lasted for 42 days. The orthogonal polynomial contrasts were used to determine the linear and quadratic effects of increasing levels of YH.
In our previous research, supplementing YH improved growth performance by enhancing body weight gain but decreased feed-to-gain ratio. In this study, compared with the control group, dietary YH addition linearly and quadratically decreased serum diamine oxidase (DAO) activity (p < 0.05). Additionally, supplementing YH linearly and/or quadratically decreased jejunal crypt depth (CD), tumor necrosis factor-alpha (TNF-α) concentration as well as mucin 2 (MUC2), interleukin-6 (IL-6), IL-1β, TNF-α, nuclear factor kappa B (NF-κB) and myeloid differentiation factor 88 (MyD88) gene expression levels (p < 0.05). Whereas the jejunal villus height (VH), VH/CD, IL-10 concentration as well as zonula occludens-1 (ZO-1) and IL-10 gene expression levels were linearly and/or quadratically increased by YH supplementation (p < 0.05).


Dietary YH supplementation improved intestinal morphology, barrier and anti-inflammatory functions while decreased intestinal permeability of broilers, which might be related with altering pertinent genes expression. This study provides evidence of YH as a promising feed additive for broilers.
Keywords: Broiler; Intestinal Barrier; Intestinal Morphology; Anti-inflammation; Yeast Hydrolysate

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