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https://doi.org/10.5713/ab.21.0288    [Accepted] Published online October 29, 2021.
Effects of dietary n-6:n-3 PUFA ratio on growth performance, blood indexes, tissue fatty acid composition and related gene expression in PPARγ signaling in finishing pigs
Jing Chen1  , Hongze Cui1  , Xianjun Liu1,*  , Jiantao Li1,2  , Jiaxing Zheng1  , Xin Li1  , Liyan Wang1 
1College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China
2Shenyang Wise Diligence Agriculture-Technology Company Limited, Xinmin, Liaoning, 110300, China
Correspondence:  Xianjun Liu, Tel: +86-24 88487156, Fax: +86-24 88487156, Email: lchenj@163.com
Received: 18 June 2021   • Revised: 27 July 2021   • Accepted: 28 September 2021
Abstract
Objective
This study investigated the effects of dietary n-6:n-3 polyunsaturated fatty acids (PUFA) ratios on growth performance, blood indexes, tissue fatty acid composition and the gene expression in finishing pigs.
Methods
Seventy-two crossbred [(Duroc × Landrace) × Yorkshire] barrows (68.5±1.8 kg) were fed one of four isoenergetic and isonitrogenous diets with n-6:n-3 PUFA ratios of 2:1, 3:1, 5:1 and 8:1.
Results
Average daily gain, average daily feed intake and gain-to-feed ratio had quadratic responses but the measurements were increased and then decreased (quadratic, p<0.05). The concentrations of serum triglyceride, total cholesterol and interleukin 6 were linearly increased (p<0.05) with increasing of dietary n-6:n-3 PUFA ratio, while that of high-density lipoprotein cholesterol tended to decrease (p = 0.062), and high-density lipoprotein cholesterol:low-density lipoprotein cholesterol ratio and leptin concentration was linearly decreased (p<0.05). The concentration of serum adiponectin had a quadratic response but the measurement was decreased and then increased (quadratic, p<0.05). The proportion of C18:3n-3 was linearly decreased (p<0.05) in the longissimus thoracis (LT) and subcutaneous adipose tissue (SCAT) as dietary n-6:n-3 PUFA ratio increasing, while the proportion of C18:2n-6 and n-6:n-3 PUFA ratio were linearly increased (p<0.05). In addition, the expression levels of peroxisome proliferator-activated receptor gamma (PPARγ) and lipoprotein lipase in the LT and SCAT, and adipocyte fatty acid binding protein and hormone-sensitive lipase (HSL) in the SCAT had quadratic responses but the measurements were increased and then decreased (quadratic, p<0.05). The expression of HSL in the LT was linearly decreased (p<0.05) with increasing of dietary n-6:n-3 PUFA ratio.

Conclusion

Dietary n-6:n-3 PUFA could regulate lipid and fatty acid metabolism in blood and tissue. Reducing dietary n-6:n-3 PUFA ratio (3:1) could appropriately suppress expression of related genes in PPARγ signaling, and result in improved growth performance and n-3 PUFA deposition in muscle and adipose tissue in finishing pigs.
Keywords: Dietary Fatty Acid; Finishing Pig; Gene Expression; Lipid Metabolism; Tissue Fatty Acid Composition


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