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Anim Biosci > Accepted Articles
https://doi.org/10.5713/ab.22.0325    [Accepted] Published online November 14, 2022.
Role of antioxidants in fertility preservation of sperm: A narrative review
Ahmed Yar Qamar1  , Muhammad Ilyas Naveed1  , Sanan Raza1  , Xun Fang2  , Pantu Kumar Roy2  , Seonggyu Bang2  , Bereket Molla Tanga2,3  , Islam M. Saadeldin2  , Sanghoon Lee2  , Jongki Cho2,* 
1College of Veterinary and Animal Sciences, Jhang 35200, Sub-campus of University of Veterinary and Animal Sciences, Lahore 54000, Pakistan
2Laboratory of Theriogenology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, South Korea
3Faculty of Veterinary Medicine, Hawassa University, 05, Hawassa, Ethiopia
Correspondence:  Jongki Cho, Tel: +82-42-821-6788, Fax: +82-42-821-8903, Email: cjki@cnu.ac.kr
Received: 29 August 2022   • Revised: 12 October 2022   • Accepted: 7 November 2022
Abstract
Abstract: Male fertility is affected by multiple endogenous stressors, including reactive oxygen species (ROS), which greatly deteriorate the fertility. However, physiological levels of ROS are required by sperm for the proper accomplishment of different cellular functions including proliferation, maturation, capacitation, acrosomal reaction, and fertilization. Excessive ROS production creates an imbalance between ROS production and neutralization resulting in oxidative stress (OS). OS causes male infertility by impairing sperm functions including reduced motility, deoxyribonucleic acid damage, morphological defects, and enhanced apoptosis. Several in-vivo and in-vitro studies have reported improvement in quality-related parameters following the use of different natural and synthetic antioxidants. In this review, we focus on the causes of OS, ROS production sources, mechanisms responsible for sperm damage, and the role of antioxidants in preserving sperm fertility.
Keywords: Antioxidants; Infertility; Oxidative Stress; Reactive Oxygen Species; Sperm


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