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Anim Biosci > Accepted Articles
https://doi.org/10.5713/ab.22.0286    [Accepted] Published online November 14, 2022.
Dietary methionine supplementation improved hair follicle development in low-protein diet-fed Angora rabbits
Man Zhao1  , Tongtong Wang1  , Bin Wang2  , Chuanhua Liu2  , Fuchang Li1,*  , Lei Liu1,* 
1Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science, Shandong Agricultural University, Taian, Shandong 271018, China
2Animal husbandry Development and Promotion Center of Mengyin County, Linyi, Shandong 276200, China
Correspondence:  Fuchang Li, Tel: +86-5388242593-8319, Fax: +86-5388241419, Email: chlf@sdau.edu.cn
Lei Liu,Email: leiliu@sdau.edu.cn
Received: 22 July 2022   • Revised: 26 September 2022   • Accepted: 30 October 2022
Abstract
Objective
Angora rabbits fed a low-protein diet exhibit decreased hair production performance. This study set out to evaluate the effects of methionine on hair properties and nitrogen metabolism in Angora rabbits fed a low-protein diet and investigated the gene expression related to hair follicle development to determine the possible molecular mechanism of methionine effects on hair follicle development.
Methods
An experiment was conducted to investigate the effects of DL-methionine addition on a low-protein diet on hair development in Angora rabbits. Angora rabbits were divided into 5 groups: fed a normal diet (control), fed a low-protein diet (LP), or fed an LP supplemented with 0.2%, 0.4%, or 0.6% DL-methionine (Met).
Results
The results showed that rabbits in the LP group had lower wool yield than the control rabbits, but the addition of 0.4%-0.6% Met to LP attenuated these effects (P<0.05). Dietary addition of 0.4%-0.6% Met to LP increased the apparent nitrogen digestibility, nitrogen utilization rate, and feed efficiency (P<0.05). Feeding LP decreased the insulin-like growth factor 1 (IGF1), keratin-associated protein (KAP) 3.1, and KAP 6.1 mRNA levels compared with the control, but the addition of 0.4% Met in LP attenuated these effects (P<0.05). Relative to the LP or control group, dietary addition of 0.4% Met increased versican mRNA levels.
Conclusion
In conclusion, the addition of Met to LP could improves wool production performance and feed efficiency and reduce nitrogen emissions in Angora rabbits. Met can promote hair follicle development, which may be associated with IGF1, KAP, and the versican signaling.
Keywords: Hair Follicle Growth; Low Protein Diet; Methionine; Nitrogen Metabolism


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