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Anim Biosci > Volume 34(3); 2021 Special Issue > Article
Animal Bioscience 2021;34(3): 321-337. Special Issue
DOI: https://doi.org/10.5713/ab.20.0851    Published online February 13, 2021.
- Special Issue -
Immunosecurity: immunomodulants enhance immune responses in chickens
Keesun Yu1  , Inhwan Choi1  , Cheol-Heui Yun1,2,3,* 
1Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
2Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea
3Center for Food Bioconvergence, Seoul National University, Seoul 08826, Korea
Correspondence:  Cheol-Heui Yun, Tel: +82-2-880-4802, Fax: +82-2-873-2271, Email: cyun@snu.ac.kr
Received: 19 December 2020   • Revised: 5 January 2021   • Accepted: 1 February 2021
Abstract
The global population has increased with swift urbanization in developing countries, and it is likely to result in a high demand for animal-derived protein-rich foods. Animal farming has been constantly affected by various stressful conditions, which can be categorized into physical, environmental, nutritional, and biological factors. Such conditions could be exacerbated by banning on the use of antibiotics as a growth promoter together with a pandemic situation including, but not limited to, African swine fever, avian influenza, and foot-and-mouth disease. To alleviate these pervasive tension, various immunomodulants have been suggested as alternatives for antibiotics. Various studies have investigated how stressors (i.e., imbalanced nutrition, dysbiosis, and disease) could negatively affect nutritional physiology in chickens. Importantly, the immune system is critical for host protective activity against pathogens, but at the same time excessive immune responses negatively affect its productivity. Yet, comprehensive review articles addressing the impact of such stress factors on the immune system of chickens are scarce. In this review, we categorize these stressors and their effects on the immune system of chickens and attempt to provide immunomodulants which can be a solution to the aforementioned problems facing the chicken industry.
Keywords: Stressor and Immune Response; Chicken Immunology; Antibiotic Growth Promoter; Immunomodulants
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