Go to Top Go to Bottom
Animal Reproduction and Physiology
Asian-Australasian Journal of Animal Sciences 2010;23(12): 1557-1565.
https://doi.org/10.5713/ajas.2010.10118    Published online October 25, 2010.
Vitellogenin Induction and Histo-metabolic Changes Following Exposure of Cyprinus carpio to Methyl Paraben
A. V. Barse, T. Chakrabarti, T. K. Ghosh, A. K. Pal, Neeraj Kumar, R. P. Raman, S. B. Jadhao
Methyl paraben (MP), which is used as a preservative in pharmaceutical and cosmetic (shampoo) products, foods and beverages, enters into the aquatic environment and can pose a potential fish health hazard. In this experiment, effects of MP were evaluated in adult male common carp (Cyprinus carpio) by exposing them to fractions (1/143rd to 1/29th) of the LC50 dose with every change of water for 28 days. Vitellogenin induction, metabolic enzymes, somatic indices and bioaccumulation were studied at weekly intervals. The 96th h LC50 of MP in fingerlings was 120 mg/L. Compared to the control, except for increases (p<0.01) in alkaline phosphatase (EC, alanine aminotransferase (EC and liver size, there were decreases (p<0.01) in activity of acid phosphatase (EC, aspartate aminotransferase (EC, and testiculosomatic index following exposure to any dose of MP. Vitellogenin induction was significantly higher (p<0.01) in exposed than unexposed (control) fish. The bioaccumulation of MP in testis, liver, brain, gills and muscle tissues of fish increased significantly (p<0.01) with increase of dose from 0.84 ppm to 1.68 ppm. Dose and duration of exposure (p<0.01) indicated that an exposure period of 1 to 2 weeks was sufficient to cause changes in the quantifiable parameters studied. Fish exposed to 4.2 ppm MP became lethargic after the 26th d. Histologically, degeneration, vacuolization and focal necrotic changes in liver and fibrosis-like changes in testicular tissue were noted.
Keywords: Methyl Paraben; Fish; Endocrine Disruption; LC50; Vitellogenin; Metabolic Enzymes; Histopathology; Bioaccumulation
METRICS Graph View
  • 23 Crossref
  • 26 Scopus
  • 4,804 View
  • 94 Download
Related articles

Editorial Office
Asian-Australasian Association of Animal Production Societies(AAAP)
Room 708 Sammo Sporex, 23, Sillim-ro 59-gil, Gwanak-gu, Seoul 08776, Korea   
TEL : +82-2-888-6558    FAX : +82-2-888-6559   
E-mail : editor@animbiosci.org               

Copyright © 2024 by Asian-Australasian Association of Animal Production Societies.

Developed in M2PI

Close layer
prev next