Current Status of Xenotransplantation - A Review

Lee, J. H.; Moran, C.

doi:2001.14.10.1497

Review paper

Review Paper

Asian-Australasian Journal of Animal Sciences 2001;14(10): 1497-1504.
https://doi.org/10.5713/ajas.2001.1497 Published online October 1, 2001.

Current Status of Xenotransplantation - A Review

J. H. Lee, C. Moran

Abstract

There is emerging interest in using xenotransplantation of porcine cells, tissues and organs for treatment of human illness. This article reviews the current status of xenotransplantation, with particular emphasis on the physiological and immunological barriers to xenotransplantation and genetic manipulations to overcome xenograft rejection. Preliminary success in xenotransplantation therapy for human Parkinson''''''''s disease using porcine foetal brain cells is described. Finally the zoonotic dangers of porcine xenotransplantation, most particularly porcine endogenous retroviruses (PERVs), are discussed.

Keywords: Xenotransplantation; Pig; Zoonoses; Porcine Endogenous Retroviruses (PERVs)

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