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Swine Nutrition and Feed Technology
Asian-Australasian Journal of Animal Sciences 2000;13(4): 516-520.
DOI: https://doi.org/10.5713/ajas.2000.516    Published online April 1, 2000.
Effects of Fermented Chub Mackerel Extract on Lipid Metabolism of Rats Fed a High-Cholesterol Diet
U. Santoso, M. Ishikawa, K. Tanaka
The present study was conducted to evaluate effect of fermented chub mackerel extract (FCME) on lipid metabolism of rats fed a diet supplemented with 1% cholesterol. Four week-old male rats were divided into three groups of 15 rats with 0, 0.1% or 0.2% FCME supplementation. In comparison with control, rats fed 0.2% FCME showed reduction of activities of acetyl-Coenzyme A carboxylase (p<0.05), 3-hydroxy-3-methyl glutaryl Coenzyme A reductase (p<0.01) and fatty acid synthetase (p<0.01). Rats fed 0.2% FCME also showed reductions in free cholesterol in the liver (p<0.05), and in concentrations of free cholesterol (p<0.05), LDL+VLDL-cholesterol (p<0.05), triglyceride (p<0.01) and phospholipid (p<0.01) in the plasma. Plasma HDL-cholesterol concentration was significantly (p<0.05) higher in treatment groups as compared with control group. Atherogenic index was also significantly lower in rats fed 0.1% or fed 0.2% supplement diet, whereas bile acid in feces was not significantly affected. The current study showed that 0.2% inclusion level of the fermented chub mackerel extracts might have hypolipidemic properties.
Keywords: Fermented Chub; Mackerel Extracts; High Cholesterol Diet; Lipid Metabolism; Atherogenic Index

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