Clinico-haematological and biochemical alterations in ethylene glycol induced acute nephrotoxicity in cow calves

Singh, D. P.; Kumar, M.; Sharma, S. P.

doi:1995.8.1.7

Article

Ruminant Nutrition and Forage Utilization

Asian-Australasian Journal of Animal Sciences 1995;8(1): 7-11.
https://doi.org/10.5713/ajas.1995.7 Published online February 1, 1995.

Clinico-haematological and biochemical alterations in ethylene glycol induced acute nephrotoxicity in cow calves

D. P. Singh, M. Kumar, S. P. Sharma

Abstract

Ethylene glycol was given orally in 6 crossbred male cow calves @ 12 ml/kg b wt for 2 days continuously to develop acute nephrotoxicity and monitor blood chemicals profile in affected calves. Progressive depression, hypersalivation, ataxia, incoordination, staggering gait, grinding of teeth, recumbency, coma, convulsions and death were prominent symptoms in affected calves. Respiration and pilse rates were increased whereas body temperature and rumen movements were low. Haematological investigations revealed increase in total erythrocyte countm platelets count and packed cell volume till death and total leukocyte count up to day 3 which decreased on day 4 and 5. these calves revealed azotaemia, reduction in calcium, chloride and potassium and rise in sodium and AST, ALT and alkaline phosphatase enzymes activity.

Keywords: Ethylene Glycol Toxicity; Haematology; Biochemistry; Nephrotoxicity; Cow Calves