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https://doi.org/10.5713/ab.21.0298    [Accepted] Published online January 3, 2022.
Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets
Hongwei Hua1  , Xiao Xu1  , Wei Tian1,2  , Pei Li1  , Huiling Zhu1  , Wenjun Wang2  , Yulan Liu1  , Kan Xiao1,* 
1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China
2College of Life Science, South-Central University for Nationalities, Wuhan 430074, China
Correspondence:  Kan Xiao, Tel: +86-18602757956, Fax: +86-27-83956175, Email: canxiaok@126.com
Received: 28 June 2021   • Revised: 28 August 2021   • Accepted: 16 November 2021
Abstract
Objective
The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury.
Methods
Thirty-two piglets were assigned by a 2 × 2 factorial experimental design including glycine supplementation and diquat challenge. After 3 weeks of feeding with a basic diet or a 1% glycine supplemented diet, piglets were challenged with diquat or saline. After 1 week later, the piglets were slaughtered and samples were collected.
Results
Our results indicated that glycine alleviated diquat induced morphological hepatic injury, decreased the activities of plasma alanine aminotransferase, aspartate aminotransferase and glutamyl transpeptidase in the piglets under diquat challenge, and increased total antioxidant capacity and antioxidative enzyme activity significantly. Adding glycine enhanced the concentrations of hepatic adenosine triphosphate and adenosine diphosphate. Transmission electron microscope observation showed that diquat induced clear hepatocytes ferroptosis and its effect could be alleviated by glycine to a certain degree. Moreover, glycine significantly affected mRNA and protein expression of ferroptosis-related signals in the liver.

Conclusion

These results demonstrated that glycine attenuated liver damage via inhibiting ferroptosis.
Keywords: Ferroptosis; Glycine; Liver; Oxidative Stress; Weaned Piglets
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