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Anim Biosci > Volume 34(4); 2021 > Article
Nonruminant Nutrition and Feed Processing
Animal Bioscience 2021;34(4): 670-679.
DOI: https://doi.org/10.5713/ajas.20.0092    Published online June 24, 2020.
Chicken serum uric acid level is regulated by glucose transporter 9
Xuedong Ding1  , Chenglu Peng1  , Siting Li1  , Manman Li1  , Xinlu Li1  , Zhi Wang1  , Yu Li1  , Xichun Wang1  , Jinchun Li1,*  , Jinjie wu1,* 
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Correspondence:  Jinchun Li, Tel: +86-18226607463, Fax: +86-0551- 65786328, Email: jinchunli64@163.com
Jinjie wu, Tel: +86-13505514926, Fax: +86-0551- 65785484, Email: wjj@ahau.edu.cn
Received: 13 February 2020   • Revised: 13 May 2020   • Accepted: 29 May 2020
Abstract
Objective
Glucose transporter 9 (GLUT9) is a uric acid transporter that is associated with uric absorption in mice and humans; but it is unknown whether GLUT9 involves in chicken uric acid regulation. This experiment aimed to investigate the chicken GLUT9 expression and serum uric acid (SUA) level.
Methods
Sixty chickens were divided into 4 groups (n = 15): a control group (NC); a sulfonamide-treated group (SD) supplemented with sulfamonomethoxine sodium via drinking water (8 mg/L); a fishmeal group (FM) supplemented with 16% fishmeal in diet; and a uric acid-injection group (IU), where uric acid (250 mg/kg) was intraperitoneally injected once a day. The serum was collected weekly to detect the SUA level. Liver, kidney, jejunum, and ileum tissues were collected to detect the GLUT9 mRNA and protein expression.
Results
The results showed in the SD and IU groups, the SUA level increased and GLUT9 expression increased in the liver, but decreased in the kidney, jejunum, and ileum. In the FM group, the SUA level decreased slightly and GLUT9 expression increased in the kidney, but decreased in the liver, jejunum, and ileum. Correlation analysis revealed that liver GLUT9 expression correlated positively, and renal GLUT9 expression correlated negatively with the SUA level.
Conclusion
These results demonstrate that there may be a feedback regulation of GLUT9 in the chicken liver and kidney to maintain the SUA balance; however, the underlying mechanism needs to be investigated in future studies.
Keywords: Chicken; Layer; Uric Acid; Glucose Transporter 9
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