Go to Top Go to Bottom
Anim Biosci > Accepted Articles
https://doi.org/10.5713/ajas.18.0224    [Accepted] Published online May 31, 2018.
WITHDRAWN:Hematological and vasodilator characteristics for high altitude acclimatization in Holstein heifers ascended to high altitude
Shuxiang Wang1, Arash Azarfar2, YaJing Wang1, Zhijun Cao1, Quangui Shi3, Shengli Li2,*
1State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, Beijing, China
2Faculty of Agriculture, Department of Animal Science, Lorestan University, Beijing, China
3Clinical Laboratory, General Hospital of Tibet Military Command, Lhasa, 850003, P. R. China., Lhasa, China
4Faculty of Agriculture, Department of Animal Science, Lorestan University, Khorramabad, Iran
Correspondence:  Shengli Li, Tel: 86+010-62731254, Fax: 010-62731254, Email: lisheng0677@163.com
Received: 16 March 2018   • Revised: 27 April 2018   • Accepted: 24 May 2018
Abstract
Objective
This study was conducted to investigate hematological and vasodilator characteristics for high altitude acclimatization in Holstein heifers ascended to high altitude.
Methods
Holstein heifers resided at low altitude (LH; Beijing, China 43 meter), and Holstein heifers ascended to high altitude (Lhasa city, Tibet; 3,658 meter) after one year exposure including hypoxia acclimated Holstein heifers (AH; with mean pulmonary arterial pressure mPAP < 41 mmHg) and Holstein heifers affected by high altitude pulmonary hypertension (HAPH; with mPAP > 49 mmHg) and crossbred cattle (CB; Holstein × Tibet cattle) born and resided in Tibet were selected to compare parameters of blood gas, blood cells and vasodilators. Each group included 15 animals with 16 to 18 month of age.
Results
The HAPH had greater mPAP than other cattle classes (P < 0.01). Alveolar ventilation (as indicated by partial pressure of carbon dioxide; PaCO2) was improved in AH and HAPH compared to LH, but it was lower in HAPH than in CB and AH (P < 0.05). In addition, LH had the greatest and HAPH had the lowest partial pressure of oxygen (PaO2) among the four cattle classes (P < 0.05). Erythropoietin and mean corpuscular hemoglobin concentration were greater in AH and HAPH than LH (P < 0.05). Serum iron was greater in AH than LA and HAPH (P < 0.05). Hypoxia exposure increased plasma nitric oxide and endothelin-1 in cattle resided in Tibet compared to LH. Additionally, AH had greater brain natriuretic peptides than HAPH and LH, and AH had greatest C-type natriuretic peptides than the other groups (P < 0.05).
Conclusion
High altitude hypoxia acclimatization was achieved in Holstein heifers ascended to high altitude via augmented alveolar ventilation, serum iron, mean corpuscular hemoglobin concentration, natriuretic peptides and nitric oxide, it enables them to tolerate the high altitude.
Keywords: Hypoxia; Hemodynamics; Vasodilators; Holstein
TOOLS
METRICS Graph View
  • 2 Crossref
  •  0 Scopus
  • 4,925 View
  • 67 Download
Related articles


Editorial Office
Asian-Australasian Association of Animal Production Societies(AAAP)
Room 708 Sammo Sporex, 23, Sillim-ro 59-gil, Gwanak-gu, Seoul 08776, Korea   
TEL : +82-2-888-6558    FAX : +82-2-888-6559   
E-mail : editor@animbiosci.org               

Copyright © 2024 by Asian-Australasian Association of Animal Production Societies.

Developed in M2PI

Close layer
prev next