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Effects of Endothelin A Receptor Antagonist BQ123 on Femoral Artery Pressure and Pulmonary Artery Pressure in Broiler Chickens |
Huiyu Wang, Jian Qiao, Mingyu Gao, Ying Yang, Kai Li, Jianlin Wang, Yong Tian, Tong Xu |
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Abstract |
Endothelin-1 (ET-1) is an important factor in regulation of cardiovascular tone in humans and mammals, but the biological function of ET-1 in the avian vascular system has not been determined. The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin A receptor (ETAR) antagonist BQ123 on the femoral artery pressure (FAP) and the pulmonary artery pressure (PAP) in broiler chickens. First, we found that plasma and lung homogenate ET-1 levels were both increased with age over the seven weeks life cyccle of broiler chickens. Second, 60 min after intravenous injection, BQ123 (0.4 ??g kg-1 and 2.0 ??g kg-1, respectively) induced a significant reduction in FAP and PAP (p<0.05). Third, chronic infusion of BQ123 (2.0 ??g kg-1 each time, two times a day) into abdominal cavities led to significant decrease in systolic pressure of the femoral (p<0.05) and pulmonary arteries (p<0.01) in broiler chickens at 7 and 14 days after treatment. Taken together, the ETAR antagonist BQ123 lead to a significant reduction of FAP and PAP, which suggests that endogenous ET-1 may be involved in the maintenance and regulation of systemic and pulmonary pressure in broiler chickens. |
Keywords:
BQ123; Endothelin-1; Femoral Artery Pressure; Pulmonary Artery Pressure; Broiler Chickens |
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