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Animal Breeding and Genetics
Asian-Australasian Journal of Animal Sciences 2007;20(9): 1342-1348.
https://doi.org/10.5713/ajas.2007.1342    Published online August 30, 2007.
DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits
X. Y. Lan, C. Y. Pan, H. Chen, C. Z. Lei, L. S. Hua, X. B. Yang, G. Y. Qiu, R. F. Zhang, Y. Z. Lun
POU1F1 is a positive regulator for GH, PRL and TSH??and its mutations associate with production traits in ruminant animals. We described a DdeI PCR-RFLP method for detecting a silent allele in the goat POU1F1 gene: TCT (241Ser)>TCG (241Ser). Frequencies of D1 allele varied from 0.600 to 1.000 in Chinese 801 goats. Significant associations of DdeI polymorphism with production traits were found in milk yield (*p<0.05), litter size (*p<0.05) and one-year-old weight (*p<0.05) between different genotypes. Individuals with genotype D1D1 had a superior performances when compared to those with genotype D1D2 (*p<0.05). Hence, the POU1F1 gene was suggested to the potential candidate gene for superior milk performance, reproduction trait and weight trait. Genotype D1D1, characterized by a DdeI PCR-RFLP detection, was recommended to geneticists and breeders as a molecular marker for better performance in the goat industry.
Keywords: Goat; POU1F1 Gene; Polymorphism; Association

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