Potential Health Benefits of Conjugated Linoleic Acid (CLA): A Review

Khanal, R. C.

doi:2004.17.9.1315

Review paper

Review Paper

Asian-Australasian Journal of Animal Sciences 2004;17(9): 1315-1328.
https://doi.org/10.5713/ajas.2004.1315 Published online September 1, 2004.

Potential Health Benefits of Conjugated Linoleic Acid (CLA): A Review

R. C. Khanal

Abstract

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of octadecadienoic acid with two conjugated double bonds. Of more than a dozen isomers of CLA found naturally in dairy and meat products from ruminants, c-9, t-11 and t-10, c-12 are the two isomers with known physiological importance, including anticarcinogenic, antidiabetic, antilipogenic, and antiatherosclerotic effects. Positive effects of CLA on immune function and bone modeling have also been reported. In spite of the compelling findings in tissue cultures and experimental animal models, its effect, dose, and mechanism of action vis-횪-vis specific isomers remains speculative. Results obtained from animal models are inconclusive and conflicting at times in humans, where the research data is limited. It appears that there is a long way to go before CLA could be accepted unequivocally as having definite effects in any or all of these physiological states and how such effects actually occur in humans. The objective of this review is to critically examine the available literature on potential health benefits of CLA observed in cell culture, animal models, and human subjects, wherever possible and to a certain extent the mechanism of action associated with these biological activities.

Keywords: Conjugated Linoleic Acid; Potential Health Benefits; Animals; Humans