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Genetic polymorphism of plasma vitamin D-binding protein (Gc) in some asian sheep |
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K. Tsunoda, K. Doge, M. A. Hasnath, H. B. Rajbhandary, W. Xu, T. Zhanchiv, B. L. Chau |
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| Abstract |
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Using polyacrylamide-gel isoelectric focusing followed by immunoblotting, genetic polymorphism of plasma vitamin D-binding protein (Gc) was examined in Asian sheep. The Gc polymorphism was revealed in the Khalkhas sheep of Mongolia, consisting of F, S and W variants, and the Yunnan native sheep of China, consisting of F and S variants. In particular, W was a new variant. The V variant detected in European sheep up to now was not observed in these sheep. The Bhyanglung, Baruwal, Kagi and Lampuchhre sheep of Nepal and local sheep of Bangladesh and Vietnam were monomorphic for the S variant. Family data and population genetic data supported the hypothesis that these variants were controlled by codominant alleles. In these Asian sheep, distribution of the Gcs allele was predominant (0.9571-1) and was seen as well in European sheep (Suffolk, Corriedale, Cheviot and Finnish Landrace) raised in Japan. Gcw allele was detected only in the Khakhas sheep with the low frequency of 0.0025. The Gcv allele was detected in the Suffolk and Corriedale sheep (0.0080 and 0.0682), but not in any of the Asian sheep studied. |
| Keywords:
Sheep; Vitamin D - Binding Protein; Gc Protein; Genetic Polymorphism; Isoelectric Focusing |
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