Gut Health of Pigs: Challenge Models and Response Criteria with a Critical Analysis of the Effectiveness of Selected Feed Additives — A Review
D. I. Adewole (Adewole DI), I. H. Kim (Kim IH), C. M. Nyachoti (Nyachoti CM)
Asian-Australas J Anim Sci. 2016;29(7):909-924.   Published online 2015 Nov 11     DOI: https://doi.org/10.5713/ajas.15.0795
Citations to this article as recorded by Crossref logo
Effect and mode of action of different doses and sources of zinc in weaning pigs using a meta-analytical and systematic review approach
Diana Luise, Clara Negrini, Federico Correa, Paolo Trevisi
Italian Journal of Animal Science.2024; 23(1): 241.     CrossRef
Gut microbiome and resistome characterization of pigs treated with commonly used post-weaning diarrhea treatments
Judith Guitart-Matas, Maria Ballester, Lorenzo Fraile, Laila Darwich, Noemí Giler-Baquerizo, Joaquim Tarres, Sergio López-Soria, Yuliaxis Ramayo-Caldas, Lourdes Migura-Garcia
Animal Microbiome.2024;[Epub]     CrossRef
Dietary Supplementation of Compound Probiotics Improves Intestinal Health by Modulated Microbiota and Its SCFA Products as Alternatives to In-Feed Antibiotics
Wenxing Wang, Guoqi Dang, Wei Hao, Anping Li, Hongfu Zhang, Shu Guan, Teng Ma
Probiotics and Antimicrobial Proteins.2024;[Epub]     CrossRef
Effects of sanitary conditions with lipopolysaccharide injection and dietary valine supplementation on growth performance, immune response, bacterial profile, and microbial metabolites in weaned pigs
Bonjin Koo, Chengbo Yang, Charles Martin Nyachoti
Archives of Animal Nutrition.2024; : 1.     CrossRef
Gut Health and Influencing Factors in Pigs
Csaba Szabó, James Kachungwa Lugata, Arth David Sol Valmoria Ortega
Animals.2023; 13(8): 1350.     CrossRef
Impact of L-Arginine and L-Glutamine supplementation on growth performance and immune status in weanling pigs challenged with Escherichia coli F4
Michael O Wellington, Tetske G Hulshof, Kristi Ernst, Anke Balemans, Greg I Page, Hubèrt M J Van Hees
Journal of Animal Science.2023;[Epub]     CrossRef
The role of dietary monoglycerides and tributyrin in enhancing performance and intestinal health function in nursery piglets
Keila Abadia Barbosa, Jansller Luiz Genova, Mayara Larissa Pazdziora, Julia Fairuz Hennig, Liliana Bury de Azevedo, Bruno Rafael de Melo Veiga, Gustavo de Amorim Rodrigues, Silvana Teixeira Carvalho, Diovani Paiano, Alysson Saraiva, Newton Tavares Escocar
Italian Journal of Animal Science.2023; 22(1): 626.     CrossRef
Effects of a Natural Polyphenolic Product from Olive Mill Wastewater on Oxidative Stress and Post-Weaning Diarrhea in Piglets
Georgios I. Papakonstantinou, Eleftherios Meletis, Konstantinos Petrotos, Polychronis Kostoulas, Nikolaos Tsekouras, Maria C. Kantere, Nikolaos Voulgarakis, Dimitrios Gougoulis, Leonidas Filippopoulos, Georgios Christodoulopoulos, Labrini V. Athanasiou, V
Agriculture.2023; 13(7): 1356.     CrossRef
Paneth cells in farm animals: current status and future direction
Chenbin Cui, Lindeng Li, Lin Wu, Xinru Wang, Yao Zheng, Fangke Wang, Hongkui Wei, Jian Peng
Journal of Animal Science and Biotechnology.2023;[Epub]     CrossRef
Summary of methodology used in enterotoxigenic Escherichia coli (ETEC) challenge experiments in weanling pigs and quantitative assessment of observed variability
Payton L Dahmer, Joel M DeRouchey, Jordan T Gebhardt, Chad B Paulk, Cassandra K Jones
Translational Animal Science.2023;[Epub]     CrossRef
The use of dexamethasone to attenuate stress responses of post-weaned pigs exposed to a mixing challenge
Samantha O Sterndale, David W Miller, Josephine P Mansfield, Jae Cheol Kim, John R Pluske
Livestock Science.2022; 255: 104785.     CrossRef
Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs
Raúl David Guevara, Jose J. Pastor, Xavier Manteca, Gemma Tedo, Pol Llonch, Cristina Óvilo
PLOS ONE.2022; 17(5): e0266524.     CrossRef
Antibiotic Use in Livestock and Residues in Food—A Public Health Threat: A Review
Oana Mărgărita Ghimpețeanu, Elena Narcisa Pogurschi, Dana Cătălina Popa, Nela Dragomir, Tomița Drăgotoiu, Oana Diana Mihai, Carmen Daniela Petcu
Foods.2022; 11(10): 1430.     CrossRef
Glyceryl butyrate attenuates enterotoxigenic Escherichia coli-induced intestinal inflammation in piglets by inhibiting the NF-κB/MAPK pathways and modulating the gut microbiota
Min Tian, Lilang Li, Zhezhe Tian, Hao Zhao, Fang Chen, Wutai Guan, Shihai Zhang
Food & Function.2022; 13(11): 6282.     CrossRef
Extra arginine supplementation during the suckling period alleviates weaning stress through the regulation of dendritic cells and Notch2 signaling in piglets
Li Dong, Zhong Peng, Jun Liu, Hongmin Li, Tianlong Wang, Shunan Wang, Hongrong Wang, Yongjiu Huo, Lihuai Yu
Food & Function.2022; 13(16): 8652.     CrossRef
Effects of dietary protein content and crystalline amino acid supplementation patterns on growth performance, intestinal histomorphology, and immune response in weaned pigs raised under different sanitary conditions
Jinyoung Lee, Jolie Caroline González-Vega, John Kyaw Htoo, Chengbo Yang, Charles Martin Nyachoti
Journal of Animal Science.2022;[Epub]     CrossRef
Effects of combined feed additives in diets to support growth performance and intestinal health profile in nursery piglets
Keila Abadia Barbosa, Jansller Luiz Genova, Mayara Larissa Pazdziora, Liliana Bury de Azevedo, Geraldyne Nunes Wendt, Paulo Evaristo Rupolo, Gustavo de Amorim Rodrigues, Silvana Teixeira Carvalho, Luiz Fernando Costa e Silva, Leandro Batista Costa, Alysso
Livestock Science.2022; 266: 105121.     CrossRef
Direct-fed Enterococcus faecium plus bacteriophages as substitutes for pharmacological zinc oxide in weanling pigs: effects on diarrheal score and growth
Sang-Hyon Oh, Jae-Cheol Jang, Chul Young Lee, Jeong Hee Han, Byung-Chul Park
Animal Bioscience.2022; 35(11): 1752.     CrossRef
Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways
Daolin Mou, Dajiang Ding, Min Yang, Xuemei Jiang, Lianpeng Zhao, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Yong Zhuo, Jian Li, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu, Bin Feng
Food & Function.2021; 12(1): 315.     CrossRef
Arundo donax L. Biomass Production in a Polluted Area: Effects of Two Harvest Timings on Heavy Metals Uptake
Tommaso Danelli, Alessio Sepulcri, Giacomo Masetti, Federico Colombo, Stefano Sangiorgio, Elena Cassani, Simone Anelli, Fabrizio Adani, Roberto Pilu
Applied Sciences.2021; 11(3): 1147.     CrossRef
Heavy-Metal Phytoremediation from Livestock Wastewater and Exploitation of Exhausted Biomass
Monika Hejna, Elisabetta Onelli, Alessandra Moscatelli, Maurizio Bellotto, Cinzia Cristiani, Nadia Stroppa, Luciana Rossi
International Journal of Environmental Research and Public Health.2021; 18(5): 2239.     CrossRef
Effects of dietary red-osier dogwood (Cornus stolonifera) on growth performance, blood profile, ileal morphology, and oxidative status in weaned pigs challenged with Escherichia coli K88+
Bonjin Koo, Sirini Budhika Amarakoon, Balachandar Jayaraman, Yaw L. Siow, Suvira Prashar, Yue Shang, O. Karmin, Charles Martin Nyachoti, Filippo Miglior
Canadian Journal of Animal Science.2021; 101(1): 96.     CrossRef
Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets
Andrea Bonetti, Benedetta Tugnoli, Andrea Piva, Ester Grilli
Animals.2021; 11(3): 642.     CrossRef
Metagenomics of Antimicrobial and Heavy Metal Resistance in the Cecal Microbiome of Fattening Pigs Raised without Antibiotics
Paiboon Tunsagool, Wuttichai Mhuantong, Sithichoke Tangphatsornruang, Nutthee Am-In, Rungtip Chuanchuen, Taradon Luangtongkum, Gunnaporn Suriyaphol, Danilo Ercolini
Applied and Environmental Microbiology.2021;[Epub]     CrossRef
Effects of different diet alternatives to replace the use of pharmacological levels of zinc on growth performance and fecal dry matter of weanling pigs
Fernanda Laskoski, Mike D Tokach, Jason C Woodworth, Joel M DeRouchey, Steve S Dritz, Jordan T Gebhardt, Robert D Goodband, Jamil E G Faccin, Fernando P Bortolozzo
Translational Animal Science.2021;[Epub]     CrossRef
Growth performance and gut health of Escherichia coli–challenged weaned pigs fed canola meal-containing diet
Jinsu Hong, Samuel Ariyibi, Linto Antony, Joy Scaria, Steven Dilberger-Lawson, David Francis, Tofuko Awori Woyengo
Journal of Animal Science.2021;[Epub]     CrossRef
In-Feed Supplementation of Resin Acid-Enriched Composition Modulates Gut Microbiota, Improves Growth Performance, and Reduces Post-Weaning Diarrhea and Gut Inflammation in Piglets
Md Karim Uddin, Shah Hasan, Md. Rayhan Mahmud, Olli Peltoniemi, Claudio Oliviero
Animals.2021; 11(9): 2511.     CrossRef
Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis
Daniel Crespo-Piazuelo, Peadar G. Lawlor, Samir Ranjitkar, Paul Cormican, Carmen Villodre, Meike A. Bouwhuis, Alan Marsh, Fiona Crispie, Ruth Rattigan, Gillian E. Gardiner
Scientific Reports.2021;[Epub]     CrossRef
Dietary Chito-oligosaccharides Improve Intestinal Immunity via Regulating Microbiota and Th17/Treg Balance-Related Immune Signaling in Piglets Challenged by Enterotoxigenic E. coli
Manrong Yu, Tiantian Meng, Wenxiang He, Hui Huang, Chunming Liu, Xiaoqin Fu, Jianhua He, Yulong Yin, Dingfu Xiao
Journal of Agricultural and Food Chemistry.2021; 69(50): 15195.     CrossRef
Effect of Resin Acid and Zinc Oxide on Immune Status of Weaned Piglets Challenged With E. coli Lipopolysaccharide
Xiaonan Guan, Regiane R. Santos, Hannele Kettunen, Juhani Vuorenmaa, Francesc Molist
Frontiers in Veterinary Science.2021;[Epub]     CrossRef
Inclusion of the direct-fed microbial Clostridium butyricum in diets for weanling pigs increases growth performance and tends to increase villus height and crypt depth, but does not change intestinal microbial abundance
Gloria A Casas, Laia Blavi, Tzu-Wen L Cross, Anne H Lee, Kelly S Swanson, Hans H Stein
Journal of Animal Science.2020;[Epub]     CrossRef
Impact of viral disease hypophagia on pig jejunal function and integrity
Emma T. Helm, Shelby M. Curry, Carson M. De Mille, Wesley P. Schweer, Eric R. Burrough, Nicholas K. Gabler, David L. Harmon
PLOS ONE.2020; 15(1): e0227265.     CrossRef
A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota
Chunxiao Ren, Yijiang Wang, Xiaofeng Lin, Hanqing Song, Qiqi Zhou, Wan Xu, Kui Shi, Jun Chen, Junshuai Song, Fang Chen, Shihai Zhang, Wutai Guan
Journal of Agricultural and Food Chemistry.2020; 68(14): 4155.     CrossRef
Influence of modern treatment regimens on serum biochemical parameters in piglets with gastroenteritis
B. O. Lukashchuk, L. G. Slivinska, A. R. Shcherbatyy, H. O. Zinko, B. V. Gutyj
Regulatory Mechanisms in Biosystems.2020; 11(1): 67.     CrossRef
A Review of the Effect of Formic Acid and Its Salts on the Gastrointestinal Microbiota and Performance of Pigs
Diana Luise, Federico Correa, Paolo Bosi, Paolo Trevisi
Animals.2020; 10(5): 887.     CrossRef
Anti-inflammatory effects of animal plasma protein supplementation in mice undergoing simultaneous gut and lung inflammation
L. Miró, C. Amat, J. Polo, M. Moretó, A. Pérez-Bosque
Food and Agricultural Immunology.2020; 31(1): 927.     CrossRef
Effects of a microencapsulated formula of organic acids and essential oils on nutrient absorption, immunity, gut barrier function, and abundance of enterotoxigenic Escherichia coli F4 in weaned piglets challenged with E. coli F4
Janghan Choi, Lucy Wang, Shangxi Liu, Peng Lu, Xiaoya Zhao, Haoming Liu, Ludovic Lahaye, Elizabeth Santin, Song Liu, Martin Nyachoti, Chengbo Yang
Journal of Animal Science.2020;[Epub]     CrossRef
Active vitamin D3-glycoside preserves weight gain and modulates the inflammatory response in broiler chickens challenged with lipopolysaccharide
Rayanne Andrade Nunes, Marcio de Souza Duarte, Paulo Henrique Reis Furtado Campos, Leandro Licursi de Oliveira, Fabyano Fonseca e Silva, Bruna Strieder Kreuz, Catharina Giovana Mirabile, Samuel Oliveira Borges, Arele Arlindo Calderano
Animal Feed Science and Technology.2020; 270: 114704.     CrossRef
Opportunities of prebiotics for the intestinal health of monogastric animals
Md A.K. Azad, Jing Gao, Jie Ma, Tiejun Li, Bie Tan, Xingguo Huang, Jie Yin
Animal Nutrition.2020; 6(4): 379.     CrossRef
Effects of reducing dietary crude protein concentration and supplementation with either laminarin or zinc oxide on the growth performance and intestinal health of newly weaned pigs
Ruth Rattigan, Torres Sweeney, Shane Maher, Marion T. Ryan, Kevin Thornton, John V. O’Doherty
Animal Feed Science and Technology.2020; 270: 114693.     CrossRef
Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge
Bruna Strieder Kreuz, Gabriel Cipriano Rocha, Paulo Henrique Reis Furtado Campos, Fabyano Fonseca e Silva, Melissa Izabel Hannas, Luiz Fernando Teixeira Albino, Samuel Oliveira Borges, Arele Arlindo Calderano
Revista Brasileira de Zootecnia.2020;[Epub]     CrossRef
A summary of feed additives, intestinal health and intestinal alkaline phosphatase in piglet nutrition
Jansller Luiz Genova, Antonio Diego Brandao Melo, Paulo Evaristo Rupolo, Silvana Teixeira Carvalho, Leandro Batista Costa, Paulo Levi de Oliveira Carvalho
Czech Journal of Animal Science.2020; 65(8): 281.     CrossRef
Biomarkers of gastrointestinal functionality in animal nutrition and health
Pietro Celi, Viviane Verlhac, Estefania Pérez Calvo, Jerome Schmeisser, Anna-Maria Kluenter
Animal Feed Science and Technology.2019; 250: 9.     CrossRef
Immune Response of Piglets Receiving Mixture of Formic and Propionic Acid Alone or with Either Capric Acid or Bacillus Licheniformis after Escherichia coli Challenge
Chunxiao Ren, Qiqi Zhou, Wutai Guan, Xiaofeng Lin, Yijiang Wang, Hanqing Song, Yinzhi Zhang
BioMed Research International.2019; 2019: 1.     CrossRef
Enterotoxigenic Escherichia coli Interferes FATP4-Dependent Long-Chain Fatty Acid Uptake of Intestinal Epithelial Enterocytes via Phosphorylation of ERK1/2-PPARγ Pathway
Zhi Li, Heyuan Liu, Bocheng Xu, Yizhen Wang
Frontiers in Physiology.2019;[Epub]     CrossRef
Evaluation of concentration of heavy metals in animal rearing system
Monika Hejna, Alessandra Moscatelli, Elisabetta Onelli, Antonella Baldi, Salvatore Pilu, Luciana Rossi
Italian Journal of Animal Science.2019; 18(1): 1372.     CrossRef
Oral Administration of Citrus Extracts in Suckling Piglets
Lidiane Pescke Pereira, João Otávio Hilgemberg, Charlise Primieri, Anna Paula Holzmann Mass, Cheila Roberta Lehnen
Brazilian Archives of Biology and Technology.2019;[Epub]     CrossRef
Gastrointestinal tract (gut) health in the young pig
John R. Pluske, Diana L. Turpin, Jae-Cheol Kim
Animal Nutrition.2018; 4(2): 187.     CrossRef
Effects of dietary supplementation of lipid-coated zinc oxide on intestinal mucosal morphology and expression of the genes associated with growth and immune function in weanling pigs
Young Min Song, Myeong Hyeon Kim, Ha Na Kim, Insurk Jang, Jeong Hee Han, Giselle Ann Fontamillas, Chul Young Lee, Byung-Chul Park
Asian-Australasian Journal of Animal Sciences.2018; 31(3): 403.     CrossRef
Effect of dietary supplementation with Yarrowia lipolytica or Saccharomyces cerevisiae yeast and probiotic additives on haematological parameters and the gut microbiota in piglets
Anna Czech, Aleksandra Smolczyk, Katarzyna Ognik, Łukasz Wlazło, Bożena Nowakowicz-Dębek, Martyna Kiesz
Research in Veterinary Science.2018; 119: 221.     CrossRef
Effects of the lipid-coated zinc oxide dietary supplement on intestinal mucosal morphology and gene expression associated with the gut health in weanling pigs challenged with enterotoxigenic Escherichia coli K88
Jeong Hee Han, Min Hye Song, Ha Na Kim, Insurk Jang, C. Young Lee, Byung-Chul Park, J. Plaizier
Canadian Journal of Animal Science.2018; 98(3): 538.     CrossRef
Antimicrobial promotion of pig growth is associated with tissue-specific remodeling of bile acid signature and signaling
Ignacio R. Ipharraguerre, Jose J. Pastor, Aleix Gavaldà-Navarro, Francesc Villarroya, Alessandro Mereu
Scientific Reports.2018;[Epub]     CrossRef
Impact of dietary spray-dried bovine plasma addition on pigs infected with porcine epidemic diarrhea virus
Mark A Duffy, Qi Chen, Jianqiang Zhang, Patrick G Halbur, Tanja Opriessnig
Translational Animal Science.2018; 2(4): 349.     CrossRef
Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies
Mohamed Rhouma, John Morris Fairbrother, Francis Beaudry, Ann Letellier
Acta Veterinaria Scandinavica.2017;[Epub]     CrossRef
Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea
Yawang Sun, Sung Woo Kim
Animal Nutrition.2017; 3(4): 322.     CrossRef
Effects of Enterococcus faecium, mannan oligosaccharide, benzoic acid and their mixture on growth performance, intestinal microbiota, intestinal morphology and blood lymphocyte subpopulations of fattening pigs
I. Giannenas, D. Doukas, A. Karamoutsios, A. Tzora, E. Bonos, I. Skoufos, A. Tsinas, E. Christaki, D. Tontis, P. Florou-Paneri
Animal Feed Science and Technology.2016; 220: 159.     CrossRef