Go to Top Go to Bottom
Animal Breeding and Genetics
Asian-Australasian Journal of Animal Sciences 2004;17(4): 543-547.
https://doi.org/10.5713/ajas.2004.543    Published online January 1, 2004.
Release of Newcastle Disease Virus Vaccine from Chitosan Microspheres In vitro and In vivo
I. K. Park, H. L. Jiang, C. H. Yun, Y. J. Choi, S. J. Kim, T. Akaike, S. I. Kim, C. S. Cho
Abstract
Newcastle disease vaccine (NDV)-loaded chitosan microspheres (NDV-CM) were prepared. Stimulatory effects of these NDV-CM on antibody response compared to free NDV were examined in vitro and in vivo. In vitro stimulation of macrophages with virus vaccine resulted in higher number of cells compared to saline-treated control. Both NDV and NDV-CM induced secretion of interleukin-1 (IL-1) in dose dependent manner and the secretion of IL-1 by NDV-CM was delayed compared to free NDV. Irrespective of vaccine formulation, NDV subunit antigen was not effective in preventing mortality of the birds after challenge. However, CM loaded with NDV made of whole viron had antibody responses and protection similar to those shown by ND-K, a commercial inactivated oil-emulsion vaccine.
Keywords: Newcastle Vaccine; Chitosan Microspheres; Macrophage; Interleukin-1
TOOLS
METRICS Graph View
  • 4 Crossref
  • 6 Scopus
  • 3,605 View
  • 42 Download
Related articles


Editorial Office
Asian-Australasian Association of Animal Production Societies(AAAP)
Room 708 Sammo Sporex, 23, Sillim-ro 59-gil, Gwanak-gu, Seoul 08776, Korea   
TEL : +82-2-888-6558    FAX : +82-2-888-6559   
E-mail : editor@animbiosci.org               

Copyright © 2024 by Asian-Australasian Association of Animal Production Societies.

Developed in M2PI

Close layer
prev next